A retrospective analysis of adjuvant and neoadjuvant therapy in patients with resectable biliary tract adenocarcinoma shows they confer no survival advantage in the treated groups, leading the authors to conclude they have no benefit. However, the study design does not allow definitive conclusions to be drawn about these treatments.
References
Glazer, E. S., Liu, P., Abdalla, E. K. Vauthey, J. N. & Curley, S. A. Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins. J. Gastrointest. Surg. 16, 1666–1671 (2012).
Horgan, A. M., Amir, E., Walter, T. & Knox, J. J. Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J. Clin. Oncol. 30, 1934–1940 (2012).
Neoptolomos, J. P. et al. Effect of adjuvant chemotherapy with fluoracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 308, 147–156 (2012).
Valle, J. et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362, 1273–1281 (2010).
Jarnagin, W. R. et al. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables and clinical outcome. J. Clin. Oncol. 24, 1152–1160 (2006).
Rocha, F. et al. Intraductal papillary neoplasm of the bile duct (IPNB): a biliary equivalent to IPMN of the pancreas? Hepatology http://dx.doi.org/10.1002/hep.25786
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Jarnagin, W. Is there a role for neoadjuvant and adjuvant therapy in biliary cancer?. Nat Rev Gastroenterol Hepatol 9, 622–623 (2012). https://doi.org/10.1038/nrgastro.2012.186
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DOI: https://doi.org/10.1038/nrgastro.2012.186
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