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Viral hepatitis

Ciclosporin versus tacrolimus for HCV transplant recipients

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Despite numerous trials, the question of whether to use ciclosporin or tacrolimus treatment following liver transplantation in patients with HCV infection is still unresolved. A large retrospective analysis now indicates that tacrolimus is preferable; however, several limitations of this study must be considered.

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References

  1. Selzner, N., Grant, D. R., Shalev, I. & Levy, G. A. The immunosuppressive pipeline: meeting unmet needs in liver transplantation. Liver Transpl. 16, 1359–1372 (2010).

    Article  PubMed  Google Scholar 

  2. Samuel, D. et al. Report of the Monothematic EASL Conference on Liver Transplantation for Viral Hepatitis (Paris, France, January 12–14, 2006). J. Hepatol. 45, 127–143 (2006).

    Article  Google Scholar 

  3. Lake, J. R. The role of immunosuppression in recurrence of hepatitis C. Liver Transpl. 9, S63–S66 (2003).

    Article  PubMed  Google Scholar 

  4. Irish, W., Arcona, S., Bowers, D. & Trotter, J. Cyclosporine versus Tacrolimus treated liver transplant recipient s with chronic hepatitis C: Outcomes analysis of the UNOS/OPTN Database. Am. J. Transplant. doi:10.1111/j.1600-6143.2011.03508.x.

    Article  CAS  PubMed  Google Scholar 

  5. Berenguer, M., Royuela, A. & Zamora, J. Immunosuppression with calcineurin inhibitors in regards to the outcome of HCV recurrence after liver transplantation: results of a meta-analysis. Liver Transpl. 13, 21–29 (2007).

    Article  Google Scholar 

  6. Levy, G. et al. Results of list2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation 77, 1632–1638 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. O'Grady, J. G. et al. Randomized controlled trial of tacrolimus versus microemulsified cyclosporine (TMC) in liver transplantation: poststudy surveillance to 3 years. Am. J. Transplant. 7, 137–141 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Berenguer, M. et al. Effect of calcineurin inhibitors in the outcome of liver transplantation in hepatitis C virus-positive recipients. Transplantation 90, 1204–1209 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. Foxton, M. R. et al. The impact of diabetes mellitus on fibrosis progression in patients transplanted for hepatitis, C. Am. J. Transplant. 6, 1922–1929 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. Berenguer, M. Systematic review of the treatment of established recurrent hepatitis C with pegylated interferon in combination with ribavirin. J. Hepatol. 9, 274–287 (2008).

    Article  Google Scholar 

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Authors and Affiliations

  1. Hepatology-Liver Transplantation Unit and Ciberehd, Digestive Medicine Service, Hospital Universitari i Politècnic La Fe, Bulevar Sur s/n, Valencia, 46026, Spain

    Marina Berenguer

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  1. Marina Berenguer
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The author declares no competing financial interests.

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Berenguer, M. Ciclosporin versus tacrolimus for HCV transplant recipients. Nat Rev Gastroenterol Hepatol 8, 422–424 (2011). https://doi.org/10.1038/nrgastro.2011.124

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