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Crohn's disease

Bacterial clearance in Crohn's disease pathogenesis

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Evidence from a recent study strongly implicates innate immunity in the etiology of Crohn's disease, with particular focus on impaired secretion of cytokines and chemokines by intestinal macrophages in response to bacterial stimuli. These findings highlight the importance of acute inflammatory responses in the first stages of disease pathogenesis.

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Figure 1: Pathology of Crohn's disease.

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Authors and Affiliations

  1. Division of Gastroenterology, IBD Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy

    Francesca Fava & Silvio Danese

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  1. Francesca Fava
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  2. Silvio Danese
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Correspondence to Silvio Danese.

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The authors declare no competing financial interests.

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Fava, F., Danese, S. Bacterial clearance in Crohn's disease pathogenesis. Nat Rev Gastroenterol Hepatol 7, 126–128 (2010). https://doi.org/10.1038/nrgastro.2010.1

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