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Primary sclerosing cholangitis

The importance of treating stenoses and infections

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The treatment of primary sclerosing cholangitis is a major challenge. Complications such as dominant bile duct stenoses and biliary infections are associated with poor outcomes. Data from a new prospective study with a follow-up of 20 years now show that dominant stenosis and fungal, but not bacterial infections reduce survival free of liver transplantation.

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References

  1. Hoffmann, C. E. E. Verschluβ der Gallenwege durch Verdickung der Wandungen. Arch. Pathol. Anat. Physiol. Klin. Med. 49, 206–215 (1867).

    Google Scholar 

  2. Tischendorf, J. J., Hecker, H., Krüger, M., Manns, M. P. & Meier, P. N. Characterization, outcome, and prognosis in 273 patients with primary sclerosing cholangitis: A single center study. Am. J. Gastroenterol. 102, 107–114 (2007).

    Article  Google Scholar 

  3. Tischendorf, J. J. et al. Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis. Scand. J. Gastroenterol. 41, 1227–1234 (2006).

    Article  Google Scholar 

  4. Angulo, P. & Lindor, K. D. Primary sclerosing cholangitis. Hepatology 30, 325–332 (1999).

    Article  CAS  Google Scholar 

  5. Wiesner, R. H. et al. Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis. Hepatology 10, 430–436 (1989).

    Article  CAS  Google Scholar 

  6. Rudolph, G. et al. Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis. J. Hepatol. 51, 149–155 (2009).

    Article  Google Scholar 

  7. Bjornsson, E. & Olsson, R. Dominant strictures in patients with primary sclerosing cholangitis—revisited. Am. J. Gastroenterol. 99, 2281 (2004).

    Article  Google Scholar 

  8. Pohl, J., Ring, A., Stremmel, W. & Stiehl, A. The role of dominant stenoses in bacterial infections of bile ducts in primary sclerosing cholangitis. Eur. J. Gastroenterol. Hepatol. 18, 69–74 (2006).

    Article  Google Scholar 

  9. Vera, A. et al. Risk factors for recurrence of primary sclerosing cholangitis of liver allograft. Lancet 360, 1943–1944 (2002).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine III (Gastroenterology, Hepatology and Metabolic Diseases), University Hospital Aachen, RWTH Aachen University, Aachen, Germany

    Jens J. W. Tischendorf & Ramin Schirin-Sokhan

Authors
  1. Jens J. W. Tischendorf
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  2. Ramin Schirin-Sokhan
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Correspondence to Jens J. W. Tischendorf.

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The authors declare no competing financial interests.

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Tischendorf, J., Schirin-Sokhan, R. The importance of treating stenoses and infections. Nat Rev Gastroenterol Hepatol 6, 691–692 (2009). https://doi.org/10.1038/nrgastro.2009.181

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