Skip to main content

Advertisement

SpringerLink
Log in

Diabetes

Should we treat infection or inflammation to prevent T2DM?

  • News & Views
  • Published:

From Nature Reviews Endocrinology

View current issue Sign up to alerts

Infections have been proposed as triggers of inflammation that could predispose individuals to type 2 diabetes mellitus. In a prospective cohort study, Jeon and co-workers provide evidence of a role of Helicobacter pylori infection in the development of type 2 diabetes mellitus, but mechanistic insight is needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Hypothetical model of the contribution of intestinal components, such as H. pylori infection, to the pathogenesis of type 2 diabetes mellitus (T2DM).

References

  1. Jeon, C. Y. et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care 35, 520–525 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Yki-Järvinen, H. in Textbook of Diabetes 4th edn Ch. 11 (eds Holt, R. I. G., Cocram, C., Flyvbjerg, A. & Goldstein, B. J.) 174–190 (Wiley-Blackwell, UK, 2010).

    Book  Google Scholar 

  3. Olefsky, J. M. & Glass, C. K. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219–246 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Dinarello, C. A., Donath, M. Y. & Mandrup-Poulsen, T. Role of IL-1β in type 2 diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 17, 314–321 (2010).

    CAS  PubMed  Google Scholar 

  5. Herder, C. et al. Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study. PLoS ONE 6, e19852 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lassenius, M. I. et al. Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care 34, 1809–1815 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Basak, C. et al. NF-kappaB- and C/EBPβ-driven interleukin-1β gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1β release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J. Biol. Chem. 280, 4279–4288 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Francois, F. et al. The effect of, H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. BMC Gastroenterol. 11, 37 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Larsen, C. M. et al. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 32, 1663–1668 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chai, W. et al. Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans. Diabetes Care 34, 1634–1638 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Vaccination and Immune Protection, Immune Response Unit, National Institute for Health and Welfare, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, 00290, Finland

    Outi Vaarala

  2. Department of Medicine, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, 00290, Finland

    Hannele Yki-Järvinen

Authors
  1. Outi Vaarala
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hannele Yki-Järvinen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Outi Vaarala.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vaarala, O., Yki-Järvinen, H. Should we treat infection or inflammation to prevent T2DM?. Nat Rev Endocrinol 8, 323–325 (2012). https://doi.org/10.1038/nrendo.2012.31

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2012.31

  • Springer Nature Limited

This article is cited by

Search

Navigation