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Salivary cortisol or cortisone?

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Measurement of salivary cortisol is used in the diagnosis of hypercortisolism and hypocortisolism. A new study by Perogamvros et al. suggests that measuring salivary cortisone, the inactive metabolite of cortisol, may be clinically useful under certain circumstances. But does analysis of salivary cortisone levels really provide an advantage over the assessment of salivary cortisol?

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Correspondence to James W. Findling.

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Raff, H., Findling, J. Salivary cortisol or cortisone?. Nat Rev Endocrinol 6, 658–660 (2010). https://doi.org/10.1038/nrendo.2010.192

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