Skip to main content

Advertisement

SpringerLink
Log in

Adrenal gland

Hypertension during remission of childhood Cushing syndrome

  • News & Views
  • Published:

From Nature Reviews Endocrinology

View current issue Sign up to alerts

Long-term adverse consequences of excess circulating glucocorticoids are gaining increasing recognition. The results of a study in children with endogenous Cushing syndrome now show that hypertension can persist even in remission, and raise important issues for the long-term management of these children's health, and potentially for the many children treated with glucocorticoids.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lodish, M. B. et al. Blood pressure in pediatric patients with Cushing syndrome. J. Clin. Endocrinol. Metab. 94, 2002–2008 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Colao, A. et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J. Clin. Endocrinol. Metab. 84, 2664–2672 (1999).

    CAS  PubMed  Google Scholar 

  3. Magiakou, M. A., Mastorakos, G., Zachman, K. & Chrousos, G. P. Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care. J. Clin. Endocrinol. Metab. 82, 1734–1738 (1997).

    CAS  PubMed  Google Scholar 

  4. Newell-Price, J., Bertagna, X., Grossman, A. B. & Nieman, L. K. Cushing's syndrome. Lancet 367, 1605–1617 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. Stewart, P. M., Walker, B. R., Holder, G., O'Halloran, D. & Shackleton, C. H. 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome. J. Clin. Endocrinol. Metab. 80, 3617–3620 (1995).

    CAS  PubMed  Google Scholar 

  6. Schäfer, S. C. et al. Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles. Am. J. Physiol. Heart Circ. Physiol. 288, H436–H444 (2005).

    Article  PubMed  Google Scholar 

  7. Koeijvoets, K. C. et al. Two common haplotypes of the glucocorticoid receptor gene are associated with increased susceptibility to cardiovascular disease in men with familial hypercholesterolemia. J. Clin. Endocrinol. Metab. 93, 4902–4908 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Newton-Cheh, C. et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat. Genet. 41, 666–676 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

  1. J. Newell-Price, Academic Unit of Diabetes, Endocrinology & Metabolism, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. j.newellprice@sheffield.ac.uk

Authors and Affiliations

  1. Academic Unit of Diabetes, Endocrinology & Metabolism, University of Sheffield, UK

    John Newell-Price

Authors
  1. John Newell-Price
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Newell-Price, J. Hypertension during remission of childhood Cushing syndrome. Nat Rev Endocrinol 5, 591–592 (2009). https://doi.org/10.1038/nrendo.2009.200

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2009.200

  • Springer Nature Limited

Search

Navigation