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C-peptide reveals possible β-cell reactivation in pregnancy

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Evidence of gradual increases in serum concentration of C-peptide as pregnancy progresses in women with type 1 diabetes mellitus provides novel insight into mechanisms of β-cell failure and regeneration, and the potential role of C-peptide in diabetes mellitus and health.

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References

  1. Sherry, N. A., Tsai, E. B. & Herold, K. C. Natural history of β-cell function in type 1 diabetes. Diabetes 54 (Suppl. 2), S32–S39 (2005).

    Article  CAS  Google Scholar 

  2. Nielsen, L. R., Rehfeld, J. F., Pedersen-Bjergaard, U., Damm, P. & Mathiesen, E. R. Pregnancy-induced rise in serum C-peptide concentrations in women with type 1 diabetes. Diabetes Care doi: dc08-1832v1-0.

  3. Löhr, M. & Klöppel, G. Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia 30, 757–762 (1987).

    Article  Google Scholar 

  4. Butler, P. C., Meier, J. J. Butler, A. E. & Bhushan, A. The replication of β cells in normal physiology, in disease and for therapy. Nat. Clin. Pract. Endocrinol. Metab. 3, 758–768 (2007).

    Article  CAS  Google Scholar 

  5. Pihoker, P., Gilliam, L. K., Hampe, C. S. & Lernmark, A. Autoantibodies in diabetes. Diabetes 54 (Suppl. 2), S52–S61 (2005).

    Article  CAS  Google Scholar 

  6. Bianchi, D. W., Zickwolf, G. K., Weil, G. J., Sylvester, S. & DeMaria, M. A. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl Acad. Sci. USA 93, 705–708 (1996).

    Article  CAS  Google Scholar 

  7. Khosrotehrani, K. & Bianchi, D. W. Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse. J. Cell. Sci. 118, 1559–1563 (2005).

    Article  CAS  Google Scholar 

  8. Panero, F. et al. Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients. Diabetes Care 32, 301–305 (2009).

    Google Scholar 

  9. Hills, C. E. & Brunskill, N. J. Cellular and physiological effects of C-peptide. Clin. Sci. (Lond.) 116, 565–574 (2009).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Leicester General Hospital, Leicester, UK

    Nigel J. Brunskill

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  1. Nigel J. Brunskill
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Correspondence to Nigel J. Brunskill.

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The author declares no competing financial interests.

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Brunskill, N. C-peptide reveals possible β-cell reactivation in pregnancy. Nat Rev Endocrinol 5, 364–365 (2009). https://doi.org/10.1038/nrendo.2009.108

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