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Pharmacogenetic tests: the need for a level playing field

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Abstract

The delivery of more personalized medicinecould be accelerated by addressing the substantial differences in the level of evidence required for the inclusion of pharmacogenetic tests in treatment guidelines, drug labelling and reimbursement schemes compared with that needed for non-genetic diagnostic tests.

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References

  1. Sauer, J. M., Ring, B. J. & Witcher, J. W. Clinical pharmacokinetics of atomoxetine. Clin. Pharmacokinet. 44, 571–590 (2005).

    Article  CAS  Google Scholar 

  2. Ciszkowski, C., Madadi, P., Phillips, M. S., Lauwers, A. E. & Koren, G. Codeine, ultrarapid-metabolism genotype, and postoperative death. N. Engl. J. Med. 361, 827–828 (2009).

    Article  CAS  Google Scholar 

  3. Zineh, I. et al. Allopurinol pharmacogenetics: assessment of potential clinical usefulness. Pharmacogenomics 12, 1741–1749 (2011).

    Article  CAS  Google Scholar 

  4. Mallal, S. et al. HLA-B*5701 screening for hypersensitivity to abacavir. N. Engl. J. Med. 358, 568–579 (2008).

    Article  Google Scholar 

  5. Chen, P. et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N. Engl. J. Med. 364, 1126–1133 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Munir Pirmohamed is at the Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, University of Liverpool, 1–5 Brownlow Street, Liverpool L69 3GL, UK.,

    Munir Pirmohamed

  2. Dyfrig A. Hughes is at the Centre for Health Economics and Medicines Evaluation, Institute of Medical and Social Care Research, Bangor University, Dean Street, Bangor LL57 1UT, UK.,

    Dyfrig A. Hughes

Authors
  1. Munir Pirmohamed
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  2. Dyfrig A. Hughes
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Correspondence to Munir Pirmohamed.

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The authors declare no competing financial interests.

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FURTHER INFORMATION

European Medicines Agency publishes guideline on use of pharmacogenetics in evaluating pharmacokinetics of medicines

SmPC for atomoxetine

SmPC for aztreonam

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Pirmohamed, M., Hughes, D. Pharmacogenetic tests: the need for a level playing field. Nat Rev Drug Discov 12, 3–4 (2013). https://doi.org/10.1038/nrd3921

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