Abstract
Renewed commitment to cardiovascular drug development is needed to combat what is likely to be the leading cause of death for the next two decades. How might this be achieved?
References
Garber, A. M. An uncertain future for cardiovascular drug development? N. Engl. J. Med. 360, 12 (2009).
World Health Organization. Cardiovascular diseases (CVDs), [online] (2009)
Yang, W. et al. Prevalence of diabetes among men and women in China. N. Engl. J. Med. 362, 1090–1101 (2010).
FDA approves updated warfarin (Coumadin) prescribing information. [online], (2007).
Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707–713 (2010).
Calhoun, D. A. et al. Resistant hypertension: diagnosis, evaluation, treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 51, 1403–1419 (2008).
Amar, L. et al. Aldosterone synthase inhibition with LCI699. A proof-of-concept study in patients with primary aldosteronism. Hypertension 13 Sep 2010 (doi: 10.1161/HYPERTENSIONAHA.110.157271).
Connolly, S. J. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 361, 1139–1151 (2009).
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A.P. is employed by Merck and Co., Inc. Whitehouse Station, New Jersey, USA.
Supplementary information
Supplementary information Figure S1
50 years of advances in cardiovascular disease therapies. (PDF 260 kb)
Supplementary information Figure S2
Alliances by therapeutic category. (PDF 191 kb)
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Plump, A. Accelerating the pulse of cardiovascular R&D. Nat Rev Drug Discov 9, 823–824 (2010). https://doi.org/10.1038/nrd3315
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DOI: https://doi.org/10.1038/nrd3315
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