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Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

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Abstract

Congruence between in vitro and animal models of disease and the corresponding human condition is a fundamental assumption of much biomedical research, but it is one that is rarely critically assessed. In the absence of such critical assessment, the assumption of congruence may be invalid for most models. Much more open discussion of this issue is required if biomedical research is to be clinically productive.

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Figure 1: Hesse's The Glass Bead Game.

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References

  1. Hesse, H. Magister Ludi (Bantam Press, New York, 1970) Originally published as Das Glasperlenspiel, Fretz and Wasmuth Verlag, Zurich, 1943.

    Google Scholar 

  2. Reynolds, L. M., Dalton, C. F. & Reynolds, G. P. Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. Neurosci. Lett. 309, 193–196 (2001).

    Article  CAS  Google Scholar 

  3. Witt, M. R. & Nielsen, M. Characterisation of the influence of unsaturated free fatty acids on brain GABA/benzodiazepine receptor binding in vitro. J. Neurochem. 62, 1432–1439 (1994).

    Article  CAS  Google Scholar 

  4. Pearson, H. Surviving a knock-out blow. Nature 415, 8–9 (2002).

    Article  CAS  Google Scholar 

  5. Horrobin, D. F. Innovation in the pharmaceutical industry. J. R. Soc. Medicine 93, 341–345 (2000).

    Article  CAS  Google Scholar 

  6. Horrobin D. F. Realism in drug discovery — could Cassandra be right? Nature Biotechnol. 19, 1099–1100 (2001).

    Article  CAS  Google Scholar 

  7. Persson, C. G., Erjefalt, J. S., Uller, L., Andersson, M. & Greiff, L. Unbalanced research. Trends Pharmacol. Sci. 22, 538–541 (2001).

    Article  CAS  Google Scholar 

  8. Rees J. Post-genome integrative biology: so that's what they call clinical science. Clin. Med. 1, 393–400 (2001).

    Article  CAS  Google Scholar 

  9. Rosenberg, L. Physician–scientists — endangered and essential. Science 283, 331–332 (1999).

    Article  CAS  Google Scholar 

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  1. Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ, Scotland

    David F. Horrobin

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  1. David F. Horrobin
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FURTHER INFORMATION

US Food and Drug Administration

European Medicines Evaluation Agency

Enclycopedia of Life Sciences

Human disease: mouse models

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Horrobin, D. Modern biomedical research: an internally self-consistent universe with little contact with medical reality?. Nat Rev Drug Discov 2, 151–154 (2003). https://doi.org/10.1038/nrd1012

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