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Legacy data sharing to improve drug safety assessment: the eTOX project

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Abstract

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

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Authors and Affiliations

  1. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, Barcelona, 08003, Spain

    Ferran Sanz & Manuel Pastor

  2. Novartis Institute for Biomedical Research, Basel, CH-4002, Switzerland

    François Pognan & Philippe Marc

  3. Bayer AG, Berlin, 13353, Germany

    Thomas Steger-Hartmann & Joerg Wichard

  4. Synapse Research Management Partners, Barcelona, 08007, Spain

    Carlos Díaz & Montserrat Cases

  5. Lhasa Ltd, Leeds, LS11 5PS, UK

    Katharine Briggs & David K. Watson

  6. Molecular Networks GmbH, Nürnberg, 90411, Germany

    Thomas Kleinöder & Chihae Yang

  7. Sanofi, Frankfurt am Main, 65926, Germany

    Alexander Amberg

  8. GlaxoSmithKline Research and Development Ltd, Stevenage, SG1 2NY, UK

    Maria Beaumont

  9. University of Leicester, Leicester, LE1 7RH, UK

    Anthony J. Brookes

  10. Technical University of Denmark (DTU), Lyngby, 2800, Denmark

    Søren Brunak

  11. Liverpool John Moores University, Liverpool, L3 3AF, UK

    Mark T. D. Cronin

  12. Universität Wien, Vienna, 1090, Austria

    Gerhard F. Ecker

  13. Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, 30625, Germany

    Sylvia Escher

  14. Pfizer Ltd, Groton, Connecticut 06340, USA. Current affiliation: AstraZeneca, Waltham, Massachusettts 02451, USA,

    Nigel Greene

  15. ESTEVE, Barcelona, 08041, Spain

    Antonio Guzmán

  16. European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridge, UK

    Anne Hersey

  17. UCB Pharma SA, Brussels, 1070, Belgium

    Pascale Jacques

  18. Janssen Pharmaceutica NV, Beerse, 2340, Belgium

    Lieve Lammens

  19. Chemotargets SL, Barcelona, 08003, Spain

    Jordi Mestres

  20. F. Hoffmann-La Roche AG, Basel, CH-4070, Switzerland

    Wolfgang Muster

  21. H. Lundbeck A/S, Copenhagen, 2500, Denmark

    Helle Northeved

  22. AstraZeneca AB, SK10 2NA Cheshire, UK. Current affiliation: Lhasa Ltd, Leeds LS11 5PS, UK,

    Marc Pinches

  23. Universitat Politècnica de València, València, 46022, Spain

    Javier Saiz

  24. Servier, Orléans, 45000, France

    Nicolas Sajot

  25. ICREA, 08010 Barcelona, Spain & Barcelona Supercomputing Center (BSC), Barcelona, 08034, Spain

    Alfonso Valencia

  26. Erasmus Universitair Medisch Centrum, Rotterdam, 3015 CE, The Netherlands

    Johan van der Lei

  27. Vrije Universiteit Amsterdam, Amsterdam, 1081, The Netherlands

    Nico P. E. Vermeulen

  28. Boehringer Ingelheim International GmbH, Biberach an der Riss, 88379, Germany

    Esther Vock

  29. Inte:Ligand GmbH, Vienna, 1070, Austria

    Gerhard Wolber

  30. Lead Molecular Design S.L., Sant Cugat del Vallès, 08172, Spain

    Ismael Zamora

Authors
  1. Ferran Sanz
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  2. François Pognan
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  3. Thomas Steger-Hartmann
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  4. Carlos Díaz
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  5. Montserrat Cases
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  6. Manuel Pastor
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  7. Philippe Marc
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  8. Joerg Wichard
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  9. Katharine Briggs
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  10. David K. Watson
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  11. Thomas Kleinöder
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  12. Chihae Yang
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  13. Alexander Amberg
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  14. Maria Beaumont
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  15. Anthony J. Brookes
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  16. Søren Brunak
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  17. Mark T. D. Cronin
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  18. Gerhard F. Ecker
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  19. Sylvia Escher
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  20. Nigel Greene
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  21. Antonio Guzmán
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  22. Anne Hersey
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  23. Pascale Jacques
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  24. Lieve Lammens
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  25. Jordi Mestres
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  26. Wolfgang Muster
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  27. Helle Northeved
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  28. Marc Pinches
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  29. Javier Saiz
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  30. Nicolas Sajot
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  31. Alfonso Valencia
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  32. Johan van der Lei
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  33. Nico P. E. Vermeulen
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  34. Esther Vock
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  35. Gerhard Wolber
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  36. Ismael Zamora
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Consortia

eTOX

Corresponding authors

Correspondence to Ferran Sanz or François Pognan.

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Competing interests

Some of the authors are employed in the pharmaceutical industry or in small and medium-sized enterprises, as indicated in the author affliations.

Supplementary information

Supplementary information S1 (box)

eTOX-related web sites and publications (PDF 173 kb)

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FURTHER INFORMATION

eTOX

eTOXlab

eTOXsys

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Sanz, F., Pognan, F., Steger-Hartmann, T. et al. Legacy data sharing to improve drug safety assessment: the eTOX project. Nat Rev Drug Discov 16, 811–812 (2017). https://doi.org/10.1038/nrd.2017.177

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