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Reducing the risk of failure: biomarker-guided trial design

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Drug candidates may fail in clinical trials for many reasons. Biomarker-guided clinical trial design can mitigate the risk of failure and enable more informative clinical experiments regardless of outcomes.

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Authors and Affiliations

  1. Biomarker Discovery-OMNI, 1 DNA Way, South San Francisco, 94080, California, USA

    Michael J. Townsend

  2. Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, 94080, California, USA

    Joseph R. Arron

Authors
  1. Michael J. Townsend
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  2. Joseph R. Arron
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Corresponding author

Correspondence to Joseph R. Arron.

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Competing interests

M.J.T. and J.R.A. are employees of Genentech Inc. and hold stock and options in the Roche Group.

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Clinical Development Success Rates: 2006–2015

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Townsend, M., Arron, J. Reducing the risk of failure: biomarker-guided trial design. Nat Rev Drug Discov 15, 517–518 (2016). https://doi.org/10.1038/nrd.2016.124

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