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Tumour microenvironment: informing on minimal residual disease in solid tumours

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From Nature Reviews Clinical Oncology

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Patients with resectable solid tumours can harbour minimal residual disease (MRD) after initial treatment, which is a potential source for subsequent metastatic relapse. The interaction between disseminated tumour cells (DTCs) and the new microenvironment in which they reside determines whether DTCs remain dormant or progress into overt metastases. We highlight the promise of liquid biopsies to inform on MRD.

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Authors and Affiliations

  1. Department of Tumour Biology, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Klaus Pantel

  2. Department of Cell and Tissue Biopathology of Tumours, Laboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre, 641 avenue du Doyen Gaston Giraud, 34093, Montpellier Cedex 5, France

    Catherine Alix-Panabières

  3. EA2415 – Help for Personalized Decision: Methodological Aspects, University Institute of Clinical Research (IURC), Montpellier University, 641 avenue du Doyen Gaston Giraud, Montpellier, 34093, Cedex 5, France

    Catherine Alix-Panabières

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  1. Klaus Pantel
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  2. Catherine Alix-Panabières
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Correspondence to Klaus Pantel.

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The authors declare no competing financial interests.

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Pantel, K., Alix-Panabières, C. Tumour microenvironment: informing on minimal residual disease in solid tumours. Nat Rev Clin Oncol 14, 325–326 (2017). https://doi.org/10.1038/nrclinonc.2017.53

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