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Adjuvant TKIs in NSCLC: what can we learn from RADIANT?

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In the RADIANT study, no difference in disease-free survival was observed for patients with non-small-cell lung cancer (NSCLC) treated with erlotinib versus placebo in the adjuvant setting. Further biomarker studies are awaited to determine whether patients with NSCLC can benefit from adjuvant therapy with tyrosine kinase inhibitors.

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References

  1. Pignon, J. P. et al. Lung adjuvant cisplatin evaluation: a pooled analysis from the LACE Collaborative Group. J. Clin Oncol. 26, 3552–3559 (2008).

    Article  Google Scholar 

  2. Tsao, M. S. et al. Erlotinib in lung cancer: molecular and clinical predictors of outcome. N. Engl. J. Med. 353, 133–144 (2005).

    Article  CAS  Google Scholar 

  3. Hirsch, F. R. et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small cell lung cancer. J. Clin. Oncol. 24, 5034–5042 (2008).

    Article  Google Scholar 

  4. Kelly, K. et al. Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non-small cell lung cancer (RADIANT): a randomized, double-blind, phase III trial. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2015.61.8918 (2015).

  5. Janjigian, Y. Y. et al. Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations. J. Thorac. Oncol. 6, 569–575 (2011).

    Article  Google Scholar 

  6. Pennel, N. A. et al. SELECT: a multicentre phase II trial of adjuvant erlotinib in resected early-stage EGFR mutation-positive NSCLC [abstract]. J. Clin. Oncol. 32 (5s Suppl.), a7514 (2014).

    Article  Google Scholar 

  7. Goss, G. D. et al. Gefitinib versus placebo in completely resected non-small cell lung cancer: result of the NCIC-CTG BR 19 Study. J. Clin. Oncol. 31, 3320–3326 (2013).

    Article  CAS  Google Scholar 

  8. Yang, J. C. et al. Afatinib versus cisplatin based chemotherapy for EGFR mutation positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6). Analysis of overall survival data from two randomized phase III trials. Lancet Oncol. 16, 141–151 (2015).

    Article  CAS  Google Scholar 

  9. National Cancer Institute. The ALCHEMIST lung cancer trials [online], (2014).

Download references

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Correspondence to Fred R. Hirsch.

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Hirsch, F., Bunn, P. Adjuvant TKIs in NSCLC: what can we learn from RADIANT?. Nat Rev Clin Oncol 12, 689–690 (2015). https://doi.org/10.1038/nrclinonc.2015.202

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