Although high-dose methotrexate is widely accepted as the most effective chemotherapeutic agent for primary CNS lymphoma, no optimal dose or dosing strategy has been established. Researchers from the International Extranodal Lymphoma Study Group used clinical trial data to explore whether or not an area under the curve model might be useful to optimize methotrexate dosing. The results strongly suggest that effective methotrexate dose is an important variable in patient outcome.
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L. E. Abrey receives grant/research support from Genentech and Novartis. She is also a consultant for Novartis and is on the speakers bureau for Schering-Plough.
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Abrey, L. Individualized methotrexate dosing in primary CNS lymphoma. Nat Rev Clin Oncol 7, 306–307 (2010). https://doi.org/10.1038/nrclinonc.2010.66
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DOI: https://doi.org/10.1038/nrclinonc.2010.66
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