Brain metastases are a challenge for the oncologist, with 20–40% of cancer patients developing intracranial metastases during the course of their illness. The incidence of brain metastases is increasing as a result of improvements in systemic therapy and imaging capabilities, and increased use of screening. Brain metastases pose not only a risk to mortality but also a risk of neurologic, cognitive and emotional difficulties.
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References
Gaspar, L. et al. Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int. J. Radiat. Oncol. Biol. Phys. 47, 1001–1006 (2000).
Khuntia, D. et al. Whole-brain radiotherapy in the management of brain metastasis. J. Clin. Oncol. 24, 1295–1304 (2006).
Patchell, R. A. et al. A randomized trial of surgery in the treatment of single metastases to the brain. N. Engl. J. Med. 322, 494–500 (1990).
Andrews, D. W. et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363, 1665–1672 (2004).
Regine, W. F. et al. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int. J. Radiat. Oncol. Biol. Phys. 52, 333–338 (2002).
Sneed, P. K. et al. A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int. J. Radiat. Oncol. Biol. Phys. 53, 519–526 (2002).
Aoyama, H. H. et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs. stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295, 2483–2491 (2006).
Kondziolka, D. J. et al. Long-term survivors after gamma knife radiosurgery for brain metastases. Cancer 104, 2784–2791 (2005).
Sawrie, S. M. et al. Predictors of distant brain recurrence for patients with newly diagnosed brain metastases treated with stereotactic radiosurgery alone. Int. J. Radiat. Oncol. Biol. Phys. 70, 181–186 (2008).
Chao, S. T. et al. Five-year survivors of brain metastases: a single-institution report of 32 patients. Int. J. Radiat. Oncol. Biol. Phys. 66, 801–819 (2006).
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Vallow, L. Stereotactic radiosurgery alone to treat brain metastases. Nat Rev Clin Oncol 6, 377–378 (2009). https://doi.org/10.1038/nrclinonc.2009.84
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DOI: https://doi.org/10.1038/nrclinonc.2009.84
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