Although imatinib mesylate therapy has dramatically improved the prognosis of patients in the advanced phases of chronic myeloid leukemia, room for improvement remains. Tyrosine kinase inhibitors are undergoing evaluation as second-line therapy for patients with imatinib-resistant disease. Kantarjian et al. recently demonstrated that once-daily dasatinib 140 mg is well tolerated and achieves a high response rate.
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F. Guilhot is a Consultant, on the Speakers bureau, and receives grant/research support from Bristol-Myers Squibb and Novartis.
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Guilhot, F., Roy, L. Dasatinib regimens for patients with chronic myeloid leukemia. Nat Rev Clin Oncol 6, 680–682 (2009). https://doi.org/10.1038/nrclinonc.2009.160
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DOI: https://doi.org/10.1038/nrclinonc.2009.160
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