Skip to main content

Advertisement

Log in

Atherosclerosis

Association between the gut microbiome and atherosclerosis

  • News & Views
  • Published:

From Nature Reviews Cardiology

View current issue Sign up to alerts

The gut microbiota has been associated with many different disorders, including cardiovascular diseases. A new study by Jie and colleagues is the first large case–control study to examine directly the enrichment of certain communities of gut bacteria in patients with atherosclerotic cardiovascular disease compared with control individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Experimental design.

References

  1. Jie, Z. et al. The gut microbiome in atherosclerotic cardiovascular disease. Nat. Commun. 8, 845 (2017).

    Article  Google Scholar 

  2. Jonsson, A. L. & Backhed, F. Role of gut microbiota in atherosclerosis. Nat. Rev. Cardiol. 14, 79–87 (2017).

    Article  CAS  Google Scholar 

  3. Org, E., Mehrabian, M. & Lusis, A. J. Unraveling the environmental and genetic interactions in atherosclerosis: central role of the gut microbiota. Atherosclerosis 241, 387–399 (2015).

    Article  CAS  Google Scholar 

  4. Li, D. Y. & Tang, W. H. W. Gut microbiota and atherosclerosis. Curr. Atheroscler. Rep. 19, 39 (2017).

    Article  Google Scholar 

  5. Tang, W. H. et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575–1584 (2013).

    Article  CAS  Google Scholar 

  6. Zhu, W. et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165, 111–124 (2016).

    Article  CAS  Google Scholar 

  7. Wang, Z. et al. Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163, 1585–1595 (2015).

    Article  CAS  Google Scholar 

  8. Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079–1094 (2015).

    Article  CAS  Google Scholar 

  9. Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258–1270 (2012).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are supported by NIH grants HL30568 and HL28481.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aldons J. Lusis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Barrington, W., Lusis, A. Association between the gut microbiome and atherosclerosis. Nat Rev Cardiol 14, 699–700 (2017). https://doi.org/10.1038/nrcardio.2017.169

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2017.169

  • Springer Nature Limited

This article is cited by

Navigation