Skip to main content
SpringerLink
Log in

Heart failure

Mitochondrial dysfunction and oxidative stress in CHF

  • News & Views
  • Published:

From Nature Reviews Cardiology

View current issue Sign up to alerts

The results of the Q-SYMBIO trial showing a reduction in mortality in patients with heart failure treated with coenzyme Q10 have substantial limitations. Nevertheless, they highlight the need to identify effective new therapies targeted at mitochondrial dysfunction and oxidative stress in heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Oxidative stress and mitochondrial dysfunction in the failing heart.

References

  1. Yancy, C. W. et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 62, e147–e239 (2013).

    Article  Google Scholar 

  2. Mortensen, S. A. et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. http://dx.doi.org/10.1016/j.jchf.2014.06.008.

  3. Burgoyne, J. R., Mongue Din, H., Eaton, P. & Shah, A. M. Redox signaling in cardiac physiology and pathology. Circ. Res. 111, 1091–1106 (2012).

    Article  CAS  Google Scholar 

  4. Oka, T. et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485, 251–255 (2012).

    Article  CAS  Google Scholar 

  5. Lygate, C. A. & Neubauer, S. Metabolic flux as a predictor of heart failure prognosis. Circ. Res. 114, 1228–1230 (2014).

    Article  CAS  Google Scholar 

  6. Hare, J. M. et al. Impact of oxypurinol in patients with symptomatic heart failure. Results from the OPT-CHF study. J. Am. Coll. Cardiol. 51, 2301–2309 (2008).

    Article  CAS  Google Scholar 

  7. Ernster, L. & Dallner, G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1271, 195–204 (1995).

    Article  Google Scholar 

  8. McMurray, J. J. V. et al. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). J. Am. Coll. Cardiol. 56, 1196–1204 (2010).

    Article  CAS  Google Scholar 

  9. O'Connor, C. M. et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301, 1439–1450 (2009).

    Article  CAS  Google Scholar 

  10. Dai, D. F. et al. Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. J. Am. Coll. Cardiol. 58, 73–82 (2011).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are supported by funding from the British Heart Foundation.

Author information

Authors and Affiliations

  1. Cardiovascular Division, King's College London British Heart Foundation Centre of Excellence, Denmark Hill Campus, 125 Coldharbour Lane, London, SE5 9NU, UK

    Darlington O. Okonko & Ajay M. Shah

Authors
  1. Darlington O. Okonko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ajay M. Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ajay M. Shah.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Okonko, D., Shah, A. Mitochondrial dysfunction and oxidative stress in CHF. Nat Rev Cardiol 12, 6–8 (2015). https://doi.org/10.1038/nrcardio.2014.189

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2014.189

  • Springer Nature Limited

This article is cited by

Search

Navigation