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Antiplatelet therapy

Clopidogrel–PPI interaction, an ongoing controversy

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Although a diminished pharmacodynamic effect of clopidogrel has been demonstrated in patients treated with proton-pump inhibitors (PPIs), whether its clinical efficacy is reduced remains highly controversial. The FDA and European Medicines Agency recommend that PPIs and clopidogrel should not routinely be coadministered, and the 2010 expert consensus guidelines support this recommendation.

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References

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Authors and Affiliations

  1. Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, Sinai Hospital of Baltimore, 2401 W. Belvedere Avenue, Baltimore, 21215, MD, USA

    Paul A. Gurbel & Udaya S. Tantry

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  1. Paul A. Gurbel
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  2. Udaya S. Tantry
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Correspondence to Paul A. Gurbel.

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Competing interests

P. A. Gurbel has acted as a consultant for AstraZeneca, Daiichi Sankyo, and Pozen; he has received Speakers' Bureau honoraria from AstraZeneca and Daiichi Sankyo; and he has received research support from AstraZeneca, Bayer, Daiichi Sankyo, Eli Lilly, Portola Pharmaceuticals, Pozen, Sanofi-Aventis and Schering-Plough. U. S. Tantry declares no competing interests.

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Gurbel, P., Tantry, U. Clopidogrel–PPI interaction, an ongoing controversy. Nat Rev Cardiol 8, 7–8 (2011). https://doi.org/10.1038/nrcardio.2010.185

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