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Systemic silencing: Mobile sRNA stabilizes genomes

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Transcriptional gene silencing is a pivotal mechanism for regulating gene expression and genome stability. In Arabidopsis, combined analyses of small RNAs (sRNAs) and DNA methylation reveals that mobile 24-nt sRNAs are involved in reinforcing genome-wide silencing of transposons through DNA methylation.

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Figure 1: Systemic gene silencing mediated by phloem delivery of sRNAs in the 21–24-nt size class.

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Correspondence to Zhaoliang Zhang, Byung-Kook Ham or William J. Lucas.

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Zhang, Z., Ham, BK. & Lucas, W. Systemic silencing: Mobile sRNA stabilizes genomes. Nature Plants 2, 16020 (2016). https://doi.org/10.1038/nplants.2016.20

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