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Cell migration

A force to be reckoned with

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A cable-like ring of biopolymers helps to pull cells together across the site of a wound. Widely thought to be homogeneous, the traction forces involved are actually remarkably heterogeneous — revealing an unexpected pattern of force generation during wound repair.

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Figure 1: Mechanisms driving transmission of cell–substrate traction forces during epithelial wound healing.

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Authors and Affiliations

  1. Miranda V. Hunter is in the Department of Cell and Systems Biology at the University of Toronto, Ontario, M5S 3G5, Canada,

    Miranda V. Hunter

  2. Rodrigo Fernandez-Gonzalez is in the Department of Cell and Systems Biology and the Institute of Biomaterials and Biomedical Engineering at the University of Toronto, Ontario, M5S 3G9, Canada, and at the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Ontario, M5G 1X8, Canada,

    Rodrigo Fernandez-Gonzalez

Authors
  1. Miranda V. Hunter
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  2. Rodrigo Fernandez-Gonzalez
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Correspondence to Rodrigo Fernandez-Gonzalez.

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Hunter, M., Fernandez-Gonzalez, R. A force to be reckoned with. Nature Phys 10, 626–627 (2014). https://doi.org/10.1038/nphys3074

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