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Are biomechanical changes necessary for tumour progression?

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Cell biophysics sheds some new light on cancer by approaching this complex problem from a materials science perspective.

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Figure 1: Cell softening and cell proliferation.
Figure 2: Tumour growth.
Figure 3: Individual and collective migration of malignant versus normal cells.
Figure 4: Contractile cells in breast tumours.

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Author notes

  1. Anatol Fritsch, Tobias Kiessling, Kenechukwu David Nnetu, Franziska Wetzel, Mareike Zink and Josef A. Käs: Anatol Fritsch, Tobias Kiessling, Kenechuku David Nnetu, Franziska Wetzel, Mareike Zink and Josef A. Käs are members of the graduate school BuildMoNa and are in the Soft Matter Physics Division, Institute for Experimental Physics I, Department of Physics and Earth Science, University of Leipzig, Linnéstrasse 5, 04103 Leipzig, Germany.

Authors and Affiliations

  1. Michael Höckel is in the Department of Obstetrics and Gynecology, Medical School, University of Leipzig, Liebigstraβe 20a, 04103 Leipzig, Germany.,

    Michael Höckel & Josef A. Käs

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  1. Anatol Fritsch
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  2. Michael Höckel
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  4. Kenechukwu David Nnetu
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Correspondence to Josef A. Käs.

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Fritsch, A., Höckel, M., Kiessling, T. et al. Are biomechanical changes necessary for tumour progression?. Nature Phys 6, 730–732 (2010). https://doi.org/10.1038/nphys1800

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