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The promises and challenges of solid-state sequencing

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Sequencing methods based on electron tunnelling could lead to breakthroughs in genomics, proteomics and glycomics, but the engineering challenges involved in delivering these devices are formidable.

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Figure 1: Three physical approaches to sequencing a moving DNA molecule.

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Acknowledgements

This work was supported in part by the National Human Genome Research Institute (grant HG 006323), F. Hoffman La Roche and Recognition AnalytiX. Useful discussions with P. Pang, P. Zhang, B. Ashcroft and W. Song are acknowledged.

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Authors and Affiliations

  1. Department of Physics and Department of Molecular Sciences, Stuart Lindsay is at the Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA,

    Stuart Lindsay

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  1. Stuart Lindsay
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Correspondence to Stuart Lindsay.

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Competing interests

The author is a co-founder of Recognition AnalytiX, a company that holds the rights to applications of recognition tunnelling technology in the fields of proteomics and glycomics.

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Lindsay, S. The promises and challenges of solid-state sequencing. Nature Nanotech 11, 109–111 (2016). https://doi.org/10.1038/nnano.2016.9

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