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Single-molecule detection

Breaking the concentration barrier

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The combination of a plasmonic nanoantenna and a nanoaperture has merged fluorescence enhancement and spatial confinement to enable single-molecule detection at biologically relevant concentrations.

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Figure 1: Nanophotonic approaches to enhance single-molecule detection.

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Authors and Affiliations

  1. Philip Tinnefeld is at the Institute for Physical and Theoretical Chemistry, TU Braunschweig, Braunschweig University of Technology, 38106 Braunschweig, Germany,

    Philip Tinnefeld

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  1. Philip Tinnefeld
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Correspondence to Philip Tinnefeld.

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Tinnefeld, P. Breaking the concentration barrier. Nature Nanotech 8, 480–482 (2013). https://doi.org/10.1038/nnano.2013.122

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