Abstract
The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learning after stress in female rats without disrupting learning itself in either sex. Thus, the hippocampus is necessary for modifying learning in males and females after acute stressful experience.
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Acknowledgements
Special thanks to D.E. Waxler for comments on the manuscript and to D. Vargas and A. Tang for technical support. This work was supported by US National Institute of Mental Health (59970) and National Science Foundation (IOB-0444364) grants to T.J.S. and a National Institute of Mental Health (AG19957-06) grant to D.A.B.
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Bangasser, D., Shors, T. The hippocampus is necessary for enhancements and impairments of learning following stress. Nat Neurosci 10, 1401–1403 (2007). https://doi.org/10.1038/nn1973
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DOI: https://doi.org/10.1038/nn1973
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