Abstract
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
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Acknowledgements
We thank R. Zhu for technical assistance. This work was supported by the US National Institutes of Health grant NS38580, the Deutsche Forschungsgemeinschaft grant NE1185/1-1 and the George E. Hewitt Foundation for Medical Research.
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Földy, C., Lee, S., Szabadics, J. et al. Cell type–specific gating of perisomatic inhibition by cholecystokinin. Nat Neurosci 10, 1128–1130 (2007). https://doi.org/10.1038/nn1952
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DOI: https://doi.org/10.1038/nn1952
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