A study in this issue reveals gene expression differences between neurons that do, and those that do not, show recovery-associated growth after stroke. The differentially expressed genes may provide potential therapeutic targets.
References
Li, S. et al. Nat. Neurosci. 13, 1496–1504 (2010).
Lakhan, S.E., Kirchgessner, A. & Hofer, M. J. Transl. Med. 7, 97 (2009).
Jiang, Q., Zhang, Z.G. & Chopp, M. Stroke 41, 410–414 (2010).
Ward, N.S. Curr. Opin. Neurol. 17, 725–730 (2004).
Nudo, R.J. Curr. Opin. Neurobiol. 16, 638–644 (2006).
Langhorne, P., Coupar, F. & Pollock, A. Lancet Neurol. 8, 741–754 (2009).
Murphy, T.H. & Corbett, D. Nat. Rev. Neurosci. 10, 861–872 (2009).
Benowitz, L.I. & Carmichael, S.T. Neurobiol. Dis. 37, 259–266 (2010).
Schwab, M.E. Curr. Opin. Neurobiol. 14, 118–124 (2004).
Markus, T.M. et al. Ann. Neurol. 58, 950–953 (2005).
Zörner, B. & Schwab, M.E. Ann. NY Acad. Sci. 1198 Suppl 1, E22–E34 (2010).
Holtmaat, A. & Svoboda, K. Nat. Rev. Neurosci. 10, 647–658 (2009).
Bérubé, N.G. et al. J. Clin. Invest. 115, 258–267 (2005).
Kernohan, K.D. et al. Dev. Cell 18, 191–202 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Schwab, M. How hard is the CNS hardware?. Nat Neurosci 13, 1444–1446 (2010). https://doi.org/10.1038/nn1210-1444
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn1210-1444
- Springer Nature America, Inc.
This article is cited by
-
Hospitalization costs among immobile patients with hemorrhagic or ischemic stroke in China: a multicenter cross-sectional study
BMC Health Services Research (2020)
-
Assembly of a new growth cone after axotomy: the precursor to axon regeneration
Nature Reviews Neuroscience (2012)