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Neuronal death or dismemberment mediated by Sox14

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The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.

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Figure 1: Sox14 and Mical function during developmental sensory dendrite pruning in Drosophila.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Jeannette M Osterloh & Marc R Freeman

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  1. Jeannette M Osterloh
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  2. Marc R Freeman
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Correspondence to Marc R Freeman.

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Osterloh, J., Freeman, M. Neuronal death or dismemberment mediated by Sox14. Nat Neurosci 12, 1479–1480 (2009). https://doi.org/10.1038/nn1209-1479

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