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Tinker to Evers to Chance: semaphorin signaling takes teamwork

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The Rho-family GTPases act downstream of axon guidance receptors, controlling proteins that remodel the cytoskeleton. New work now suggests that these GTPases also team up to regulate activation of the semaphorin-3A receptor itself.

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Figure 1: A model for plexin-A1 activation and growth-cone repulsion by semaphorin-3A.

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  1. the Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139-4307, Massachusetts, USA

    Paul A Garrity

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  1. Paul A Garrity
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Garrity, P. Tinker to Evers to Chance: semaphorin signaling takes teamwork. Nat Neurosci 8, 1635–1636 (2005). https://doi.org/10.1038/nn1205-1635

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