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Flipping the switch from electrical to chemical communication

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Immature neurons in many brain regions are electrically coupled through gap junctions, which are lost as chemical synaptic transmission matures. This developmental uncoupling is now shown to require NMDA receptor activation.

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Figure 1: NMDA receptor–mediated uncoupling of developing hypothalamic neurons.

Ann Thomson

References

  1. Montoro, R.J. & Yuste, R. Brain Res. Brain Res. Rev. 47, 216–226 (2004).

    Article  CAS  Google Scholar 

  2. Arumugam, H., Liu, X., Colombo, P.J., Corriveau, R.A. & Belousov, A.B. Nat. Neurosci. 8, 1720–1726 (2005).

    Article  CAS  Google Scholar 

  3. Bennett, M.V. & Zukin, R.S. Neuron 41, 495–511 (2004).

    Article  CAS  Google Scholar 

  4. Kandler, K. & Katz, L.C. J. Neurosci. 18, 1419–1427 (1998).

    Article  CAS  Google Scholar 

  5. Yuste, R., Peinado, A. & Katz, L.C. Science 257, 665–669 (1992).

    Article  CAS  Google Scholar 

  6. Mentis, G.Z., Diaz, E., Moran, L.B. & Navarrete, R. J. Physiol. (Lond.) 544, 757–764 (2002).

    Article  CAS  Google Scholar 

  7. Ghosh, A., Ginty, D.D., Bading, H. & Greenberg, M.E. J. Neurobiol. 25, 294–303 (1994).

    Article  CAS  Google Scholar 

  8. Silva, A.J., Kogan, J.H., Frankland, P.W. & Kida, S. Annu. Rev. Neurosci. 21, 127–148 (1998).

    Article  CAS  Google Scholar 

  9. Deisseroth, K., Bito, H. & Tsien, R.W. Neuron 16, 89–101 (1996).

    Article  CAS  Google Scholar 

  10. Lonze, B.E. & Ginty, D.D. Neuron 35, 605–623 (2002).

    Article  CAS  Google Scholar 

  11. Szabo, T.M., Faber, D.S. & Zoran, M.J. J. Neurosci. 24, 112–120 (2004).

    Article  CAS  Google Scholar 

  12. Waters, J., Schaefer, A. & Sakmann, B. Prog. Biophys. Mol. Biol. 87, 145–170 (2005).

    Article  Google Scholar 

  13. Pastor, A.M., Mentis, G.Z., de la Cruz, R.R., Diaz, E. & Navarrete, R. J. Neurophysiol. 89, 793–805 (2003).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, 15261, Pennsylvania, USA

    Karl Kandler & Edda Thiels

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  1. Karl Kandler
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  2. Edda Thiels
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Kandler, K., Thiels, E. Flipping the switch from electrical to chemical communication. Nat Neurosci 8, 1633–1634 (2005). https://doi.org/10.1038/nn1205-1633

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