Skip to main content
Log in

Specifying motor neurons: up and down and back to front

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

A recent study in Nature shows that the columnar fate of motor neurons in the embryonic spinal cord is imposed by cross-repressive patterns of Hox-c expression. This Hox expression is in turn controlled by graded FGF signaling.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Motor neuron specification in the dorsoventral and rostrocaudal axis of the spinal cord.

Debbie Maizels

References

  1. Tosney, K.W., Hotary, K.B. & Lance-Jones, C. Bioessays 17, 379–382 (1995).

    Article  CAS  Google Scholar 

  2. Dasen, J., Liu, J.-P. & Jessell, T. Nature 425, 926–933 (2003).

    Article  CAS  Google Scholar 

  3. Novitch, B.G., Wichterle, H., Jessell, T.M. & Sockanathan, S. Neuron 40, 81–95 (2003).

    Article  CAS  Google Scholar 

  4. Diez del Corral, R. et al. Neuron 40, 65–79 (2003).

    Article  CAS  Google Scholar 

  5. Ensini, M., Tsuchida, T.N., Belting, H.G. & Jessell, T.M. Development 125, 969–982 (1998).

    CAS  PubMed  Google Scholar 

  6. Liu, J.P., Laufer, E. & Jessell, T.M. Neuron 32, 997–1012 (2001).

    Article  CAS  Google Scholar 

  7. Bel-Vialar, S., Itasaki, N. & Krumlauf, R. Development 129, 5103–5115 (2002).

    CAS  PubMed  Google Scholar 

  8. Jessell, T.M. Nat. Rev. Genet. 1, 20–29 (2000).

    Article  CAS  Google Scholar 

  9. Sockanathan, S., Perlmann, T. & Jessell, T.M. Neuron 40, 97–111 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, W. Specifying motor neurons: up and down and back to front. Nat Neurosci 6, 1247–1249 (2003). https://doi.org/10.1038/nn1203-1247

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1203-1247

  • Springer Nature America, Inc.

Navigation