Abstract
Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate1 indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.
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References
McClearn, G.E. et al. Science 276, 1560–1563 (1997).
Buhot, M.C. Curr. Opin. Neurobiol. 7, 243–254 (1997).
Sheline, Y.I., Mintun, M.A., Moerlein, S.M. & Snyder, A.Z. Am. J. Psychiatry 159, 430–435 (2002).
Squire, L.R. & Alvarez, P. Curr. Opin. Neurobiol. 5, 169–177 (1995).
Meneses, A. Cell. Mol. Neurobiol. 22, 675–688 (2002).
Ozaki, N. et al. Biol. Psychiatry 40, 1267–1272 (1996).
Ozaki, N. et al. J. Neurochem. 68, 2186–2193 (1997).
Gothert, M., Propping, P., Bonisch, H., Bruss, M. & Nothen, M.M. Ann. NY Acad. Sci. 861, 26–30 (1998).
Kandel, E.R. Science 294, 1030–1038 (2001).
Rey, A. L'examen Clinique en Psychologie (Presses Universitaires de France, Paris, 1958).
Acknowledgements
This work was supported by grants from the Swiss National Science Foundation (3232-058420.99 to D.Q., and 32-068859, PP00B-68859/1 to A.P.), by the Hartmann-Müller-Stiftung (D.Q.) and by the National Center for Competence in Research (NCCR) “Neuronal Plasticity and Repair”.
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de Quervain, DF., Henke, K., Aerni, A. et al. A functional genetic variation of the 5-HT2a receptor affects human memory. Nat Neurosci 6, 1141–1142 (2003). https://doi.org/10.1038/nn1146
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DOI: https://doi.org/10.1038/nn1146
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