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Making glutamatergic neurons from GABAergic progenitors

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The mature phenotype of CNS neurons is thought to be set at an early progenitor stage. A study now shows that expression of Fezf2 alone can turn striatal GABAergic precursors into glutamatergic corticofugal neurons.

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Figure 1: Schematic depicting progenitors in the developing striatum (left) and cerebral cortex (right), indicating some of their respective fate determinants and the final neurons these cells generate.

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Authors and Affiliations

  1. Magdalena Götz is at the Institute for Stem Cell Research, Helmholtz Zentrum München, and the Institute of Physiology, University of Munich, Munich, Germany.,

    Magdalena Götz

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  1. Magdalena Götz
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Correspondence to Magdalena Götz.

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Götz, M. Making glutamatergic neurons from GABAergic progenitors. Nat Neurosci 13, 1308–1309 (2010). https://doi.org/10.1038/nn1110-1308

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