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Bringing SOD1 into the fold

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Could similar changes in superoxide dismutase 1 (SOD1) underlie both familial and sporadic amyotrophic lateral sclerosis (ALS)? A new study finds that wild-type SOD1 from sporadic ALS tissues shows conformational changes similar to those seen in familial ALS and may be pathogenic as a result of the same mechanism.

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Figure 1: Mechanisms of motor neuron degeneration.

K. Vicari

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Authors and Affiliations

  1. Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California, USA

    Sami Barmada & Steven Finkbeiner

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  1. Sami Barmada
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  2. Steven Finkbeiner
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Correspondence to Steven Finkbeiner.

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The authors declare no competing financial interests.

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Barmada, S., Finkbeiner, S. Bringing SOD1 into the fold. Nat Neurosci 13, 1303–1304 (2010). https://doi.org/10.1038/nn1110-1303

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