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Glycogen: a Trojan horse for neurons

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Neural activity leads to the mobilization of energy from glycogen in astrocytes. A new paper reports that neurons have an ambivalent relationship with glycogen: they can synthesize it themselves, but that synthesis induces apoptosis. Presumably for this reason, neurons normally inhibit glycogen synthesis through two redundant pathways.

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Figure 1: Glycogen metabolism in the brain and its dysregulation in Lafora disease.

Katie Ris-Vicari

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Authors and Affiliations

  1. Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, AAB 1 33 (Bâtiment AAB), Station 15, Lausanne, CH-1015, Switzerland

    Pierre J Magistretti & Igor Allaman

  2. Département de Psychiatrie, Pierre Magistretti is also in the Centre de Neurosciences Psychiatriques, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. pierre.magistretti@epfl.ch,

    Pierre J Magistretti

Authors
  1. Pierre J Magistretti
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  2. Igor Allaman
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Magistretti, P., Allaman, I. Glycogen: a Trojan horse for neurons. Nat Neurosci 10, 1341–1342 (2007). https://doi.org/10.1038/nn1107-1341

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