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Senseless makes sense for spinocerebellar ataxia-1

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Why are some neurons selectively targeted for death in neurodegenerative diseases? A recent paper combines genetics in the fruit fly and mouse to uncover mechanisms underlying the vulnerability of Purkinje cells in spinocerebellar ataxia-1.

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Figure 1: Tsuda et al. demonstrate homologous pathways that mediate ataxin-1–induced neurodegeneration in mouse and Drosophila models of SCA-1.

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Authors and Affiliations

  1. Department of Pathology at Brigham and Women's Hospital and Harvard Medical School, 77 Louis Pasteur Ave., Boston, 02115, Massachusetts, USA

    Vikram Khurana, Tudor A Fulga & Mel B Feany

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  1. Vikram Khurana
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  2. Tudor A Fulga
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  3. Mel B Feany
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Khurana, V., Fulga, T. & Feany, M. Senseless makes sense for spinocerebellar ataxia-1. Nat Neurosci 8, 1422–1424 (2005). https://doi.org/10.1038/nn1105-1422

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