Abstract
Sleep enhances plasticity in neocortex, and thereby improves sensory learning1. Here we show that sleep itself undergoes changes as a consequence of waking experience during a late critical period in cats and mice. Dark-rearing produced a robust and reversible decrement of slow-wave electrical activity during sleep that was restricted to visual cortex and impaired by gene-targeted reduction of NMDA receptor function.
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Stickgold, R., Hobson, J.A., Fosse, R. & Fosse, M. Science 294, 1052–1057 (2001).
Steriade, M., McCormick, D.A. & Sejnowski, T.J. Science 262, 679–685 (1993).
Mednick, S.C. et al. Nat. Neurosci. 5, 677–681 (2002).
Daw, N. Visual Development (Plenum, New York, 1995).
Crair, M.C., Gillespie, D.C. & Stryker, M.P. Science 279, 566–570 (1998).
Frank, M.G., Issa, N.P. & Stryker, M.P. Neuron 30, 275–287 (2001).
Jouvet-Mounier, D., Astic, L. & Lacote, D. Dev. Psychobiol. 2, 216–239 (1970).
Gordon, J.A. & Stryker, M.P. J. Neurosci. 16, 3274–3286 (1996).
Mower, G.D., Caplan, C.J., Christen, W.G. & Duffy, F.H. J. Comp. Neurol. 235, 448–466 (1985).
Steigerwald, F. et al. J. Neurosci. 20, 4573–4581 (2000).
Fagiolini, M. et al. Proc. Natl. Acad. Sci. USA 100, 2854–2859 (2003).
Kiyama, Y. et al. J. Neurosci. 18, 6704–6712 (1998).
Ito, I., Sakimura, K., Mishina, M. & Sugiyama, H. Neurosci. Lett. 203, 69–71 (1996).
Kattler, H., Dijk, D.J. & Borbely, A.A. J. Sleep Res. 3, 159–164 (1994).
Vyazovskiy, V., Borbely, A.A. & Tobler, I. J. Sleep Res. 9, 367–371 (2000).
Acknowledgements
We thank H. Mori and M. Mishina (Univ. Tokyo) for kindly providing NR2A KO mice, S. Fujishima for animal care, and M. Fagiolini for inspirational comments.
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Miyamoto, H., Katagiri, H. & Hensch, T. Experience-dependent slow-wave sleep development. Nat Neurosci 6, 553–554 (2003). https://doi.org/10.1038/nn1064
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DOI: https://doi.org/10.1038/nn1064
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