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Synchronous versus asynchronous transmitter release: a tale of two types of inhibitory neurons

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Inhibitory cortical neurons are thought to generate temporally precise signals important for information processing, but a new study shows that CCK-expressing interneurons continue to release GABA for several hundred milliseconds after bursts of action potentials.

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Figure 1: Differences in PV and CCK cell synapses onto a dentate granule cell in the hippocampus.

Ann Thomson

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Authors and Affiliations

  1. Department of Comparative Medicine, Stanford University School of Medicine, 300 Pasteur Drive R314, Palo Alto, 94035-5342, California, USA

    Shaul Hestrin & Mario Galarreta

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  1. Shaul Hestrin
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  2. Mario Galarreta
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Hestrin, S., Galarreta, M. Synchronous versus asynchronous transmitter release: a tale of two types of inhibitory neurons. Nat Neurosci 8, 1283–1284 (2005). https://doi.org/10.1038/nn1005-1283

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