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Ancient viral protein enrages astrocytes in multiple sclerosis

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Syncytin is a viral envelope protein encoded in the human genome. New work in this issue indicates that it is activated in multiple sclerosis astrocytes and microglia, contributing to the inflammation-induced myelin destruction that causes disease symptoms.

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Figure 1: Role of syncytin in the pathogenesis of MS.

Michael Pace

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Authors and Affiliations

  1. Laboratory of Neurosciences,

    Mark P Mattson & Dennis D Taub

  2. Laboratory of Immunology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, 21224, Maryland, USA

    Mark P Mattson & Dennis D Taub

Authors
  1. Mark P Mattson
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  2. Dennis D Taub
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Mattson, M., Taub, D. Ancient viral protein enrages astrocytes in multiple sclerosis. Nat Neurosci 7, 1021–1023 (2004). https://doi.org/10.1038/nn1004-1021

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