Skip to main content

Advertisement

SpringerLink
Log in

Epigenetic control of myelin repair

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Although the CNS has a robust innate ability to repair demyelinated axons, this capacity appears to dissipate with age. A study in this issue suggests that epigenetic processes participate in myelin repair and that the epigenetic response is less dynamic in older individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Diagram depicting the epigenetic control of OPC maturation.

References

  1. Kantarci, O. & Wingerchuk, D. Curr. Opin. Neurol. 19, 248–254 (2006).

    Article  Google Scholar 

  2. Shen, S. et al. Nat. Neurosci. 11, 1024–1034 (2008).

    Article  CAS  Google Scholar 

  3. Trapp, B.D. & Nave, K. Annu. Rev. Neurosci. 31, 247–269 (2008).

    Article  CAS  Google Scholar 

  4. Matsushima, G.K. & Morell, P. Brain Pathol. 11, 107–116 (2001).

    Article  CAS  Google Scholar 

  5. Shields, S.A., Gilson, J.M. & Blakemore, W.F. Glia 28, 77–83 (1999).

    Article  CAS  Google Scholar 

  6. Miller, R.H. & Mi, S. Nat. Neurosci. 10, 1351–1354 (2007).

    Article  CAS  Google Scholar 

  7. Kondo, T. & Raff, M. Science 289, 1754–1757 (2000).

    Article  CAS  Google Scholar 

  8. Kondo, T. & Raff, M. Genes Dev. 18, 2963–2972 (2004).

    Article  CAS  Google Scholar 

  9. Lyssiotis, C.A. et al. Proc. Natl. Acad. Sci. USA 104, 14982–14987 (2007).

    Article  CAS  Google Scholar 

  10. Bhaumik, S.R., Smith, E. & Shilatifard, A. Nat. Struct. Mol. Biol. 14, 1008–1016 (2007).

    Article  CAS  Google Scholar 

  11. Fukuda, H., Sano, N., Muto, S. & Horikoshi, M. Brief. Funct. Genomic. Proteomic. 5, 190–208 (2006).

    Article  CAS  Google Scholar 

  12. Shen, S. & Casaccia-Bonnefil, P. J. Mol. Neurosci. 35, 13–22 (2008).

    Article  CAS  Google Scholar 

  13. Marin-Husstege, M., Muggironi, M., Liu, A. & Casaccia-Bonnefil, P. J. Neurosci. 22, 10333–10345 (2002).

    Article  CAS  Google Scholar 

  14. Shen, S., Li, J. & Casaccia-Bonnefil, P. J. Cell Biol. 169, 577–589 (2005).

    Article  CAS  Google Scholar 

  15. Liu, A. et al. J. Neurosci. 27, 7339–7343 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, The author is at the Jack Miller Center for Peripheral Neuropathy, University of Chicago, 5841 South Maryland Ave., MC2030, Chicago, Illinois 60637-1470, USA. bpopko@uchicago.edu,

    Brian Popko

Authors
  1. Brian Popko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Popko, B. Epigenetic control of myelin repair. Nat Neurosci 11, 987–988 (2008). https://doi.org/10.1038/nn0908-987

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0908-987

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation