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Huntingtin's critical cleavage

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The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.

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Figure 1: Effects of mutating the caspase-6 cleavage site on the function and toxicity of polyglutamine-expanded htt.

Katie Ris

References

  1. Graham, R.K. et al. Cell 125, 1179–1191 (2006).

    Article  CAS  Google Scholar 

  2. Gatchel, J.R. & Zoghbi, H.Y. Nat. Rev. Genet. 6, 743–755 (2005).

    Article  CAS  Google Scholar 

  3. Ikeda, H. et al. Nat. Genet. 13, 196–202 (1996).

    Article  CAS  Google Scholar 

  4. Emamian, E.S. et al. Neuron 38, 375–387 (2003).

    Article  CAS  Google Scholar 

  5. Steffan, J.S. et al. Science 304, 100–104 (2004).

    Article  CAS  Google Scholar 

  6. Takeyama, K. et al. Neuron 35, 855–864 (2002).

    Article  CAS  Google Scholar 

  7. Tsuda, H. et al. Cell 122, 633–644 (2005).

    Article  CAS  Google Scholar 

  8. Kim, Y.J. et al. Proc. Natl. Acad. Sci. USA 98, 12784–12789 (2001).

    Article  CAS  Google Scholar 

  9. Graham, R.K. et al. Neurobiol. Dis. 21, 444–455 (2006).

    Article  CAS  Google Scholar 

  10. Van Raamsdonk, J.M. et al. Hum. Mol. Genet. 14, 3823–3835 (2005).

    Article  CAS  Google Scholar 

  11. Klement, I.A. et al. Cell 95, 41–53 (1998).

    Article  CAS  Google Scholar 

  12. Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M.E. Cell 95, 55–66 (1998).

    Article  CAS  Google Scholar 

  13. Hodgson, J.G. et al. Hum. Mol. Genet. 5, 1875–1885 (1996).

    Article  CAS  Google Scholar 

  14. Leavitt, B.R. et al. J. Neurochem. 96, 1121–1129 (2006).

    Article  CAS  Google Scholar 

  15. Goehler, H. et al. Mol. Cell 15, 853–865 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neuroscience and the Department of Molecular and Human Genetics, Program in Developmental Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, 77030, Texas, USA

    John D Fryer & Huda Y Zoghbi

Authors
  1. John D Fryer
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  2. Huda Y Zoghbi
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Correspondence to Huda Y Zoghbi.

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Fryer, J., Zoghbi, H. Huntingtin's critical cleavage. Nat Neurosci 9, 1088–1089 (2006). https://doi.org/10.1038/nn0906-1088

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