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Pathological tau: a loss of normal function or a gain in toxicity?

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Neurofibrillary tangles, composed of tau protein, are a central feature of Alzheimer disease. A new paper challenges the idea that these tau inclusions alone cause disease by showing that they can be dissociated from memory impairment and neuronal loss.

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Figure 1: A schematic of the misfolding, fibrillization and sequestration of tau into neurofibrillary tangles and neuritic tau pathology.

Ann Thomson

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, and the Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    John Q Trojanowski & Virginia M-Y Lee

Authors
  1. John Q Trojanowski
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  2. Virginia M-Y Lee
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Trojanowski, J., Lee, VY. Pathological tau: a loss of normal function or a gain in toxicity?. Nat Neurosci 8, 1136–1137 (2005). https://doi.org/10.1038/nn0905-1136

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