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Wnts send axons up and down the spinal cord

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Certain Wnts attract ascending somatosensory axons up the spinal cord toward the brain. A study in this issue shows that other Wnts guide corticospinal axons down the spinal cord, not by an attractive mechanism but by repulsion through the receptor Ryk.

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Figure 1: Wnts guide axons up and down the spinal cord.

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  1. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3-5, Vienna, A-1030, Austria

    Barry J Dickson

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  1. Barry J Dickson
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Dickson, B. Wnts send axons up and down the spinal cord. Nat Neurosci 8, 1130–1132 (2005). https://doi.org/10.1038/nn0905-1130

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