After exocytosis, synaptic vesicles must be retrieved and refilled with neurotransmitter to supply the needs of an active neuron. A new report finds that synaptic activity, through the retrograde action of nitric oxide (NO), regulates the rate of this synaptic vesicle recycling. These findings suggest that NOmight enhance the synaptic strength of coincidentally active neurons.
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Erin Boyle
References
Harata, N. et al. Trends Neurosci. 24, 637–643 (2001).
Murthy, V.N., Sejnowski, T.J. & Stevens, C.F. Neuron 18, 599–612 (1997).
Micheva, K.D., Buchanan, J., Holz, R.W. & Smith, S.J. Nat. Neurosci. 6, 925–932 (2003).
Micheva, K.D., Holz, R.W. & Smith, S.J. J. Cell Biol. 154, 355–368 (2001).
Martin, T.F.J. Curr. Opin. Cell Biol. 13, 493–499 (2001).
Osborne, S.L., Meunier, F.A. & Schiavo, G. Neuron 32, 9–12 (2001).
Miesenbock, G., De Angelis, D.A. & Rothman, J.E. Nature 394, 192–195 (1998).
Li, Z. & Murthy, V.N. Neuron 31, 593–606 (2001).
Ozkan, E.D. & Ueda, T. Jpn. J. Pharmacol. 77, 1–10 (1998).
Holz, R.W. et al. J. Biol. Chem. 275, 17878–17885 (2000).
Lin, H.C. & Gilman, A.G. J. Biol. Chem. 271, 27979–27982 (1996).
Henkel, A.W. & Almers, W. Curr. Opin. Neurobiol. 6, 350–357 (1996).
Gandhi, S.P. & Stevens, C.F. Nature 423, 607–613 (2003).
Pyle, J.L., Kavalali, E.T., Piedras-Renteria, E.S. & Tsien, R.W. Neuron 28, 221–231 (2000).
Sankaranarayanan, S. & Ryan, T.A. Nat. Neurosci. 4, 129–36 (2001).
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Sullivan, J. NO going back. Nat Neurosci 6, 905–906 (2003). https://doi.org/10.1038/nn0903-905
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DOI: https://doi.org/10.1038/nn0903-905
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