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Less is more: progenitor death and cortical size

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Cerebral cortex size in individuals and species is determined by cortical progenitor mitosis and death during embryogenesis. EphA signaling—important in axon guidance and patterning—also seems to be critical in regulating the survival of cortex progenitors.

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Figure 1: Radial unit lineage model of cortical neurogenesis.

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Authors and Affiliations

  1. Department of Neurobiology and the Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, 06511, Connecticut, USA

    Pasko Rakic

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  1. Pasko Rakic
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Rakic, P. Less is more: progenitor death and cortical size. Nat Neurosci 8, 981–982 (2005). https://doi.org/10.1038/nn0805-981

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