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The synaptic Aβ hypothesis of Alzheimer disease

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Aβ peptide is linked to Alzheimer pathology, but its toxic mechanism remains unclear. New work shows that Aβ leads to internalization of NMDA receptors, reducing their availability at synapses. The authors also suggest a molecular mechanism for this endocytosis.

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Figure 1: Effects of Aβ42 on NMDA receptor internalization at the synapse.

References

  1. Glenner, G.G. & Wong, C.W. Biochem. Biophys. Res. Commun. 120, 885–890 (1984).

    Article  CAS  PubMed  Google Scholar 

  2. Selkoe, D.J. Neuron 6, 487–498 (1991).

    Article  CAS  PubMed  Google Scholar 

  3. Snyder, E. et al. Nat. Neurosci. 8, 1049–1056 (2005).

    Article  Google Scholar 

  4. Tanzi, E. Riv. Sperim. Freniatr. Med. 19, 419–472 (1893).

    Google Scholar 

  5. Tanzi, R.E. & Bertram, L. Cell 120, 545–555 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Terry, R.D. et al. Ann. Neurol. 30, 572–580 (1991).

    Article  CAS  PubMed  Google Scholar 

  7. Larson, J., Lynch, G., Games, D. & Seubert, P. Brain Res. 840, 23–35 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Lambert, M.P. et al. Proc. Natl. Acad. Sci. USA 95, 6448–6453 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Walsh, D.M. et al. Nature 416, 535–539 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Cleary, J.P. et al. Nat. Neurosci. 8, 79–84 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Moir, R.D. et al. J. Biol. Chem. 280, 17458–17463 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Dougherty, J.J., Wu, J. & Nichols, R.A. J. Neurosci. 23, 6740–6747 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kamenetz, F. et al. Neuron 37, 925–937 (2003).

    Article  CAS  PubMed  Google Scholar 

  14. Lee, H.G., Moreira, P.I., Zhu, X., Smith, M.A. & Perry, G. Am. J. Pathol. 165, 1461–1464 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Klyubin, I. et al. Nat. Med. 11, 556–561 (2005).

    Article  CAS  PubMed  Google Scholar 

Download references

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  1. Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, Massachusetts, USA

    Rudolph E Tanzi

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  1. Rudolph E Tanzi
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Tanzi, R. The synaptic Aβ hypothesis of Alzheimer disease. Nat Neurosci 8, 977–979 (2005). https://doi.org/10.1038/nn0805-977

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