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Central melanocortin signaling regulates cholesterol

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Melanocortin signaling in the CNS, which crucially regulates feeding and energy expenditure, also regulates the expression of a hepatic cholesterol re-uptake receptor. Thus, the brain in rodents directly controls the levels of circulating high-density cholesterol species. The relevance to human cholesterol metabolism remains unknown.

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Figure 1: Regulation of circulating HDL levels by the hypothalamus.

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Authors and Affiliations

  1. University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

    Yi-Chun Loraine Tung & Giles S H Yeo

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  1. Yi-Chun Loraine Tung
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  2. Giles S H Yeo
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Correspondence to Giles S H Yeo.

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The authors declare no competing financial interests.

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Tung, YC., Yeo, G. Central melanocortin signaling regulates cholesterol. Nat Neurosci 13, 779–780 (2010). https://doi.org/10.1038/nn0710-779

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