Skip to main content
SpringerLink
Log in

Fool me once, shame on me—fool me twice, blame the ACC

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

The anterior cingulate cortex (ACC) is thought to detect unfavorable outcomes and thus influence behavior. A new paper reports that ACC-lesioned monkeys respond normally to reduced rewards, but do not maintain their improved behavioral strategy. The ACC thus is not a simple error detector, but an integrator of past reward experience.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Monkeys with lesions in the anterior cingulate cortex (ACC) correct errors but fail to maintain the new rewarded behavior.

Ann Thomson

References

  1. Terborgh, J. Five New-World Primates: A Study in Comparative Ecology (Monographs in Behavior and Ecology) (Princeton Univ. Press, Princeton, New Jersey, 1984).

    Book  Google Scholar 

  2. Stephens, D.W. & Krebs, J.R. Foraging Theory (Princeton Univ. Press, Princeton, New Jersey, 1986).

    Google Scholar 

  3. Schultz, W. Annu. Rev. Psychol. 57, 87–115 (2006).

    Article  Google Scholar 

  4. Charnov, E.L. Theor. Popul. Biol. 9, 129–136 (1976).

    Article  CAS  Google Scholar 

  5. Kennerley, S.W., Walton, M.E., Behrens, T.E.J., Buckley M.J. & Rushworth, M.F.S. Nat. Neurosci. 9, 940–947 (2006).

    Article  CAS  Google Scholar 

  6. Paus, T. Nat. Rev. Neurosci. 2, 417–424 (2001).

    Article  CAS  PubMed Central  Google Scholar 

  7. Carter, C.S. et al. Proc. Natl. Acad. Sci. USA 97, 1944–1948 (2000).

    Article  CAS  PubMed Central  Google Scholar 

  8. Gehring, W.J., Goss, B., Coles, M.G.H., Meyer, D.E. & Donchin, E. Psychol. Sci. 4, 385–390 (1993).

    Article  Google Scholar 

  9. Botvinick, M.M., Braver, T.S., Barch, D.M., Carter, C.S. & Cohen, J.D. Psychol. Rev. 108, 624–652 (2001).

    Article  CAS  Google Scholar 

  10. Rescorla, R.A. Annu. Rev. Neurosci. 11, 329–352 (1988).

    Article  CAS  Google Scholar 

  11. Nakamura, K., Roesch, M.R. & Olson, C.R. J. Neurophysiol. 93, 884–908 (2005).

    Article  PubMed Central  Google Scholar 

  12. Shima, K. & Tanji, J. Science 282, 1335–1338 (1998).

    Article  CAS  PubMed Central  Google Scholar 

  13. Herrnstein, R.J. J. Exp. Anal. Behav. 4, 267–272 (1961).

    Article  CAS  PubMed Central  Google Scholar 

  14. Sugrue, L.P., Corrado, G.S. & Newsome, W.T. Science 304, 1782–1787 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  15. Aston-Jones, G. & Cohen, J.D. J. Comp. Neurol. 493, 99–110 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology, Center for Neuroeconomic Studies, and Center for Cognitive Neuroscience, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Benjamin Y Hayden & Michael L Platt

Authors
  1. Benjamin Y Hayden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael L Platt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayden, B., Platt, M. Fool me once, shame on me—fool me twice, blame the ACC. Nat Neurosci 9, 857–859 (2006). https://doi.org/10.1038/nn0706-857

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0706-857

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation